Aplastic Anemia

Additional information that give more knowledge about anemia,
When your body stops producing enough new blood cells you may have Aplastic Anemia. Aplastic Anemia can happen to anyone at any age and is a serious condition. Bone marrow requires a sufficient number of cells to be able to replenish blood cells effectively. So when marrow is not in good functioning as it should be this is called 'Aplastic'.
Anemia refers to a low blood cell count. In individuals that have a reduction in red blood cell concentration in their blood would be diagnosed with Anemia. On the other hand, in Aplastic Anemia all three blood cell types are affected, they have a lower count of platelets along with lower counts of red and white blood cells.
A.Some Causes of that Condition
Bones marrow has a function that is very critical. It contains stem cells that produce red cells, white cells and platelets. If something ends up damaging your bone marrow then Aplastic anemia will develop. Exposure to toxic chemicals can cause damage resulting in Aplastic anemia.
Exposure to a chemical known as benzene, found in gasoline, is the main cause of the aplastic anemia, although researchers have found that it can differ depending on the patient. Leukemia can develop as a result of people being exposed to benzene and they do not even know it. Drugs, dyes, gasoline and certain synthetic rubbers contain benzene also.You should be carefull .
B.Symptoms and Treatment
There are several symptoms that go along with Aplastic anemia. Some of the conditions are mentioned below:
aplastic anemia
* Excessive bruising

* Extremely pale skin tone

* Higher risk of infection

* Fatigue


Without treatment, the condition can be fatal. Patients are given medicine on a daily basis by their doctors to suppress the immune system from attacking cells in your bone marrow. There have been many cases where patients have been given a bone marrow transplant because it is seen as a possible cure.
If you feel you may have been around benzene you need to contact an experienced lawyer that knows your rights and will guide you in the right direction. You may be suffering from Aplastic anemia and a lawyer can help you.
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More Details

A rare and serious blood disorder in which bone marrow stops making enough new blood cells. aplastic anemia, normal production of all blood cells—red cells, white cells, and platelets—slows or stops. This is because the stem cells have been damaged. The cause of this damage is often unknown.

ETIOLOGY:
Aplastic anemia is caused by damage to stem cells in the bone marrow. Stem cells normally develop into three types of blood cells: red blood cells, white blood cells, and platelets. When stem cells are damaged, they do not grow into healthy blood cells.
In more than half of people with aplastic anemia, the cause of the damage to stem cells is unknown. Some research suggests that stem cell damage may occur because the body’s immune system attacks its own cells by mistake.

The cause of acquired aplastic anemia has been linked to outside agents, as well as to diseases. Outside agents include toxins such as pesticides, arsenic, and benzene; radiation and chemotherapy used to treat cancer; and medicines such as chloramphenicol, an antibiotic now rarely used in the United States. Infectious diseases also can cause aplastic anemia. Some of these diseases are hepatitis, Epstein-Barr virus, cytomegalovirus (si-to-MEG-a-lo-VI-rus), parvovirus B19, and HIV. Autoimmune diseases, such as lupus and rheumatoid arthritis (ROO-ma-toyd ar-THRI-tis), also can cause this condition.
Some inherited genetic disorders can lead to aplastic anemia. These include Fanconi anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita

MANIFESTATIONS:
Aplastic anemia is suspected when test results indicate that all three blood cell levels are extremely low, but the cells themselves have a relatively normal appearance. It remains a rare disease, striking only two to six of every 1 million people annually in the United States and Europe.
In addition to low blood cell counts, aplastic anemia is characterized by other physical symptoms of anemia such as pale skin and fingernails, rapid pulse, heart murmur and fatigue. Children also may exhibit abnormal bleeding including multiple bruises, nosebleeds, bleeding gums and small hemorrhages under the skin as well as infection, especially fever. However, each child may experience symptoms differently. Other possible symptoms include:

• Headache
• Dizziness
• Nausea
• Shortness of breath
• Blood in stool
• Sinus tenderness
• Enlarged liver or spleen
• Oral thrush, which produces white patches on a red, moist, swollen surface anywhere in the mouth.